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M94B0794.TXT
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1994-11-11
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Document 0794
DOCN M94B0794
TI Pediatric HIV associated non-Hodgkin's lymphomas (Meeting abstract).
DT 9412
AU Shad A; Bhatia K; Hamdy N; Mueller B; Pizzo P; Whang Peng J; Jaffe E;
Magrath I; Pediatric Branch, Pathology Dept., NCI, Bethesda, MD 20892
SO Proc Annu Meet Am Assoc Cancer Res; 35:A1140 1994. Unique Identifier :
AIDSLINE ICDB/94602826
AB HIV infected children, like HIV infected adults, are at increased risk
for development of non-Hodgkin's lymphomas (NHL). However, there is very
little information available on the histological, cytogenetic and
molecular features of pediatric HIV associated NHLs. We present here the
pathological and biological features of 5 such pediatric lymphomas.
Histologically, unlike non-immunosuppressed children, where Burkitt's
lymphoma is the most common form of NHL seen, pediatric HIV associated
NHLs are more variable. 3 tumors analyzed were small non-cleaved cell
lymphomas (SNCC), 1 large cell immunoblastic lymphoma, 1 anaplastic
large cell lymphoma (Ki-1+), and 1 B cell lymphoma with plasmacytoid
features. Cytogenetic studies demonstrated that 2 of 3 SNCC lymphomas
had t(8;14) while 1 had t(9;19); the large cell immunoblastic lymphoma
had an inv(12). By Southern blot analyses, both tumors with t(8;14) had
a rearrangement of the c-myc gene. EBV was identified in 2 SNCC
lymphomas, but not in the other histological subtypes. Only 2 SNCC
lymphomas carried a mutated p53. These findings suggest that the
spectrum of lymphoma subtypes is broader in a pediatric HIV population
compared to that seen in non-immunosuppressed children.
DE Blotting, Southern Child Chromosome Aberrations Gene Expression
Regulation, Neoplastic/PHYSIOLOGY Human Lymphoma,
AIDS-Related/CLASSIFICATION/GENETICS/*PATHOLOGY Neoplasm Staging Tumor
Markers, Biological/GENETICS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).